While the cause of Chronic Fatigue Syndrome remains unknown, certain risk factors have been identified:
Age: CFS is commonly diagnosed in individuals in their 40s and 50s [1,2].
Sex: Women are two to four times more likely to experience CFS than men .
Genetics: CFS has been observed in family members, suggesting a potential role of both genes and environment, although further research is needed .
Stress: Many CFS patients report the onset of symptoms following periods of extreme emotional or physical stress, which affects the hypothalamic-pituitary-adrenal axis (HPA axis) responsible for stress response and regulating various body processes.
Immune System: Some researchers speculate that CFS may be linked to how a person’s immune system responds to stress or infection, exhibiting similarities to autoimmune disorders where the immune system attacks healthy tissues .
Gut/Nutritional Imbalances: Studies suggest a possible connection between CFS and conditions like celiac disease, food sensitivities, or allergies, with digestive issues commonly reported by CFS patients .
Although some risk factors like age and sex are beyond control, individuals can still take steps to support a healthy immune system, reduce stress levels, and maintain a balanced diet. These measures not only help protect against CFS but also contribute to overall well-being and prevention of various health problems.